Analysis Tools
growth/size/body
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• mice exhibit large, hemorrhagic cysts originating from antral follicles
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reproductive system
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• in the seminiferous tubules
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• unlike in wild-type mice, follicles exhibit a marked deficiency in granulosa cells
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
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• mice exhibit a reduction in the number of glandular interstitial cells compared to wild-type mice and these cells appear loosely arranged as a consequence of edema
• mice exhibit the presence of mast-like cells in the ovaries unlike wild-type mice
• ovaries contain fully differentiated Sertoli cells
• however, female mice do not exhibit an increase in anti-Mullerian hormone
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• however, primordial, and primary follicles are normal
• Sertoli cells develop between ovarian follicles after the onset of puberty and appear to arise within the epithelium of atretic follicles
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• mice exhibit an excess of follicles at advanced stages of atresia
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• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
• unlike in wild-type mice, prepubertal antral follicles are surrounded by a single layer or loosely packed organization of granulosa cells and a single layer of theca cells, and contain a suspended oocyte completely detached from the follicular wall
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• theca cell proliferation is decreased compared to in wild-type mice
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• mice exhibit large, hemorrhagic cysts originating from antral follicles
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• mice exhibit a straightening of the rete testis unlike wild-type mice
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• mice exhibit a straightening of the seminiferous tubules unlike wild-type mice
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• ovaries contain fully differentiated Sertoli cells
• Sertoli cells in the ovaries develop between ovarian follicles after the onset of puberty and appear to arise within the epithelium of atretic follicles
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thin uterus
(
J:64426
)
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• despite normal genital tract anterior-posterior development, mice exhibit a 2-fold reduction in uterus diameter and wall thickness
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• mice exhibit a reduction in cell number and size that affects all tissue types
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small vagina
(
J:64426
)
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• despite normal genital tract anterior-posterior development, mice exhibit a 2-fold reduction in vagina diameter and wall thickness
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• mice exhibit hypoplastic vaginas with a reduction in both cell number and size that affects all tissue types
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homeostasis/metabolism
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• mice fail to superovulate when treated with gonadotropins and follicles fail to even reach the preovulatory stage unlike in similarly treated wild-type mice
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endocrine/exocrine glands
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• unlike in wild-type mice, follicles exhibit a marked deficiency in granulosa cells
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
|
|
|
• mice exhibit a reduction in the number of glandular interstitial cells compared to wild-type mice and these cells appear loosely arranged as a consequence of edema
• mice exhibit the presence of mast-like cells in the ovaries unlike wild-type mice
• ovaries contain fully differentiated Sertoli cells
• however, female mice do not exhibit an increase in anti-Mullerian hormone
|
|
|
• however, primordial, and primary follicles are normal
• Sertoli cells develop between ovarian follicles after the onset of puberty and appear to arise within the epithelium of atretic follicles
|
|
|
• mice exhibit an excess of follicles at advanced stages of atresia
|
|
|
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
• unlike in wild-type mice, prepubertal antral follicles are surrounded by a single layer or loosely packed organization of granulosa cells and a single layer of theca cells, and contain a suspended oocyte completely detached from the follicular wall
|
|
|
• theca cell proliferation is decreased compared to in wild-type mice
|
|
|
• mice exhibit large, hemorrhagic cysts originating from antral follicles
|
|
|
• mice exhibit a straightening of the rete testis unlike wild-type mice
|
|
|
• mice exhibit a straightening of the seminiferous tubules unlike wild-type mice
|
|
|
• ovaries contain fully differentiated Sertoli cells
• Sertoli cells in the ovaries develop between ovarian follicles after the onset of puberty and appear to arise within the epithelium of atretic follicles
|
cellular
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• in the seminiferous tubules
|
|
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• unlike in wild-type mice, follicles exhibit a marked deficiency in granulosa cells
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
|
