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Phenotypes Associated with This Genotype
Genotype
MGI:3798303
Allelic
Composition
Esr1tm1.1Mma/Esr1tm1.1Mma
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1.1Mma mutation (0 available); any Esr1 mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in the seminiferous tubules

reproductive system
• in the seminiferous tubules
• mice exhibit a reduction in the number of glandular interstitial cells compared to wild-type mice and these cells appear loosely arranged as a consequence of edema
• mice exhibit the presence of mast-like cells in the ovaries unlike wild-type mice
• mice exhibit an excess of follicles at advanced stages of atresia
• however, primordial, primary and antral follicles are normal
• unlike in wild-type mice, prepubertal ovaries contain large antral follicles with well-defined antrums
• mice exhibit large, hemorrhagic cysts originating from antral follicles
• mice exhibit a straightening of the rete testis unlike wild-type mice
• mice exhibit a straightening of the seminiferous tubules unlike wild-type mice
• unlike in wild-type mice, cyclic changes to the uterus and vagina are absent

growth/size/body
• mice exhibit large, hemorrhagic cysts originating from antral follicles

homeostasis/metabolism
• superovulation induced by gonadotropin treatment is severely reduced compared to in wild-type mice

endocrine/exocrine glands
• mice exhibit a reduction in the number of glandular interstitial cells compared to wild-type mice and these cells appear loosely arranged as a consequence of edema
• mice exhibit the presence of mast-like cells in the ovaries unlike wild-type mice
• mice exhibit an excess of follicles at advanced stages of atresia
• however, primordial, primary and antral follicles are normal
• unlike in wild-type mice, prepubertal ovaries contain large antral follicles with well-defined antrums
• mice exhibit large, hemorrhagic cysts originating from antral follicles
• mice exhibit a straightening of the rete testis unlike wild-type mice
• mice exhibit a straightening of the seminiferous tubules unlike wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory