Phenotypes Associated with This Genotype

Genotype
MGI:3797796

• Allelic Composition: Isl1^tm2Gan/Isl1^tm2Gan; Pou4f2^tm1(ALPP)Whk/Pou4f2^tm2Whk; Tg(Six3-cre)69Frty/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina

• adult mice only have about 5% the number of retinal ganglion cells as do the controls

• genesis of RGCs are not affected as they are present in E13.5 embryos

optic nerve hypoplasia ( J:134978 )

• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present

nervous system

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina

• adult mice only have about 5% the number of retinal ganglion cells as do the controls

• genesis of RGCs are not affected as they are present in E13.5 embryos

optic nerve hypoplasia ( J:134978 )

• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present