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Phenotypes Associated with This Genotype
Genotype
MGI:3797795
Allelic
Composition
Isl1tm2Gan/Isl1tm2Gan
Tg(Six3-cre)69Frty/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm2Gan mutation (0 available); any Isl1 mutation (37 available)
Tg(Six3-cre)69Frty mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
• mice have much thinner optic nerves, optic chiasms and optic tracts

nervous system
• mice have much thinner optic nerves, optic chiasms and optic tracts
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
• mice have much thinner optic nerves, optic chiasms and optic tracts


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory