Mouse Genome Informatics
cn
    Myocdtm1Msp/Myocdtm1Msp
Tg(Wnt1-cre)11Rth/0

involves: 129/Sv * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• majority of mutants die before P3

cardiovascular system
• the architecture of the neointima and tunica media of the ductus arteriosus is disturbed
• increase in fibronectin and laminin in the ductus arteriosus
• all mutants at P2 exhibit patent ductus arteriosus
• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus
• however, patterning of the cardiac outflow tract and great arteries is normal
• the smooth muscle cells of the ductus arteriosus are heterogeneous in size with a loss of spindle-like cell morphology
• the smooth muscle cells of the ductus arteriosus have relatively few myofibers and show an increase in synthetic organelles, including the rough ER and Golgi

homeostasis/metabolism
• pups become cyanotic shortly after birth

muscle
• the smooth muscle cells of the ductus arteriosus are heterogeneous in size with a loss of spindle-like cell morphology
• the smooth muscle cells of the ductus arteriosus have relatively few myofibers and show an increase in synthetic organelles, including the rough ER and Golgi

cellular
• all mutants at P2 exhibit patent ductus arteriosus
• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus
• however, patterning of the cardiac outflow tract and great arteries is normal

Mouse Models of Human Disease
OMIM IDRef(s)
Patent Ductus Arteriosus 607411 J:131288