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Phenotypes Associated with This Genotype
Genotype
MGI:3797650
Allelic
Composition
Myocdtm1Msp/Myocdtm1Msp
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myocdtm1Msp mutation (0 available); any Myocd mutation (24 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• majority of mutants die before P3

cardiovascular system
• the architecture of the neointima and tunica media of the ductus arteriosus is disturbed
• increase in fibronectin and laminin in the ductus arteriosus
• all mutants at P2 exhibit patent ductus arteriosus
• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus
• however, patterning of the cardiac outflow tract and great arteries is normal
• the smooth muscle cells of the ductus arteriosus are heterogeneous in size with a loss of spindle-like cell morphology
• the smooth muscle cells of the ductus arteriosus have relatively few myofibers and show an increase in synthetic organelles, including the rough ER and Golgi

homeostasis/metabolism
• pups become cyanotic shortly after birth

muscle
• the smooth muscle cells of the ductus arteriosus are heterogeneous in size with a loss of spindle-like cell morphology
• the smooth muscle cells of the ductus arteriosus have relatively few myofibers and show an increase in synthetic organelles, including the rough ER and Golgi

cellular
• all mutants at P2 exhibit patent ductus arteriosus
• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus
• however, patterning of the cardiac outflow tract and great arteries is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory