Mouse Genome Informatics
cn
    Myocdtm1Msp/Myocdtm1Msp
Tg(Wnt1-cre)11Rth/0

involves: 129/Sv * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• majority of mutants die before P3

cardiovascular system
• the architecture of the neointima and tunica media of the ductus arteriosus is disturbed
• increase in fibronectin and laminin in the ductus arteriosus
• all mutants at P2 exhibit patent ductus arteriosus
• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus
• however, patterning of the cardiac outflow tract and great arteries is normal
• the smooth muscle cells of the ductus arteriosus are heterogeneous in size with a loss of spindle-like cell morphology
• the smooth muscle cells of the ductus arteriosus have relatively few myofibers and show an increase in synthetic organelles, including the rough ER and Golgi

homeostasis/metabolism
• pups become cyanotic shortly after birth

muscle
• the smooth muscle cells of the ductus arteriosus are heterogeneous in size with a loss of spindle-like cell morphology
• the smooth muscle cells of the ductus arteriosus have relatively few myofibers and show an increase in synthetic organelles, including the rough ER and Golgi

Mouse Models of Human Disease
OMIM IDRef(s)
Patent Ductus Arteriosus 607411 J:131288