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Phenotypes Associated with This Genotype
Genotype
MGI:3797606
Allelic
Composition
Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4Gt(LST020)Byg mutation (0 available); any Lgr4 mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Microphthalmia, iris hypoplasia, and iridiocorneal abnormalities in Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg mice

mortality/aging
• about 60% of mice die within the first day of birth

growth/size/body
• embryos are retarded in growth
• weight of mice on the day of birth is 60-70% that of littermate controls

vision/eye
• 10% of mice have inflammation in the cornea
• the iridocorneal angle is smaller to varying degrees in these mice
• in 12.5% of the mice, the corneal angle is completely closed due to adhesion of the iris to the cornea
• the Schlemm's canal is much smaller in both length and width
• the trabecular meshworks are compressed and contain many fewer trabecular beams with smaller beam size
• the ciliary body is much smaller containing less folding and fewer cells
• mice have significantly larger pupils
• the iris only contains a small layer of brown tissue around the cornea and is much thinner and shorter than in wild-type mice
• the stroma of the iris is smaller with 12-18 stromal cells present per pupil compared to 25-35 stromal cells present in wild-type pupils
• the thickness in the middle of the stroma is also dramatically reduced due to hypoplasia of smooth muscle cells that reside in the stroma
• the majority of mice with opaque corneas also have vascularization
• 8% of all adult mice have cornea vascular pannus
• in 12.5% of the mice, the corneal angle is completely closed due to adhesion of the iris to the cornea
• corneal epithelium is thinner than controls starting at 10 days of age with epithelial cells appearing shrunken and more compact
• the cornea stroma of adult mice is significantly thinner
• cornea epithelial plugs exist in 16% of mice
• in addition, 8% of mice have lost their surface smoothness
• corneal epithelium is thinner than controls starting at 10 days of age with epithelial cells appearing shrunken and more compact
• cell proliferation and cell differentiation are significantly slower in these mice
• the lamellar arrangement of collagen in cornea is disorganized with fibers crossing each other random
• 10% of mice have cystic-like lesions present in the cornea
• 40% of mice have opacity of the cornea
• the ratio of soluble to insoluble alphaA-crystalin is lower in these mice
• lens fibers are disorganized and abnormally larger in the cortical zone of lens in mice with cataracts
• 26% of adult mice have cataracts with opacity ranging from total to partial
• in mice without len fiber anomalies, the lens size is significantly smaller than in controls
• 75% of male mice that survive birth have a small eye phenotype
• 37% of female survivors have the small eye phenotype
• there is a significant loss of ganglion cells in 10 of 24 mice over 6 months of age
• the inner nuclear layer is thinned and disarranged in 10 of 24 mice over 6 months of age
• the inner nuclear layer is thinned and disarranged in 10 of 24 mice over 6 months of age
• the outer nuclear layer is thinned and disarranged in 10 of 24 mice over 6 months of age
• the outer nuclear layer is thinned and disarranged in 10 of 24 mice over 6 months of age

embryo
• embryos are retarded in growth

nervous system
• there is a significant loss of ganglion cells in 10 of 24 mice over 6 months of age

immune system
• 10% of mice have inflammation in the cornea

cardiovascular system
• the majority of mice with opaque corneas also have vascularization
• 8% of all adult mice have cornea vascular pannus

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
glaucoma DOID:1686 J:134299


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory