Analysis Tools
nervous system
| N |
• astrocyte motility and morphology is similar to wild-type cells
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• cells show reduced numbers of intermediate filaments relative to wild-type
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cellular
| N |
(J:125280)
• astrocytes are morphologically similar to wild-type
(J:125659)
• astrocyte motility in culture is similar to wild-type
(J:125659)
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• cells show reduced numbers of intermediate filaments relative to wild-type
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• homing of Vim-deficient lymphocytes is markedly reduced in vivo both in wild-type and Vim-null mice
• wild-type or Vim-deficient lymphocytes home more effectively to mesenteric lymph nodes and spleens of null mice than wild-type animals
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• number of transmigrated leukocytes in Vim-deficient mice is significantly higher than in wild-type; transmigration efficiency of adherent cells is 2.6-fold higher than in wild-type mice
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• adhesion of Vim-null leukocytes (PMBCs) to wild-type or Vim-deficient endothelial cells is markedly reduced; wild-type peripheral blood mononuclear cells (PMBCs) to Vim-deficient endothelial cells also
• in vivo, number of adherent leukocytes (bound to endothelial cells for >30 seconds) is significantly lower than in wild-type mice
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• velocity of rolling cells in mutants is 3 times higher than in wild-type
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immune system
| N |
• lipopolysaccharide (LPS) and Il-21 induce similar neutrophilic invasion when administered into air pouch of mutant or wild-type mice
• cells from LPS-induced air pouches incubated with different agonists show similar levels and rates of apoptosis in controls and mutants; anti-apoptotic cytokine treatment delays neutrophil apoptosis similarly in mutants and controls
• phagocytosis in induced cells is not different from wild-type cells
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• homing of Vim-deficient lymphocytes is markedly reduced in vivo both in wild-type and Vim-null mice
• wild-type or Vim-deficient lymphocytes home more effectively to mesenteric lymph nodes and spleens of null mice than wild-type animals
|
|
• number of transmigrated leukocytes in Vim-deficient mice is significantly higher than in wild-type; transmigration efficiency of adherent cells is 2.6-fold higher than in wild-type mice
|
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• adhesion of Vim-null leukocytes (PMBCs) to wild-type or Vim-deficient endothelial cells is markedly reduced; wild-type peripheral blood mononuclear cells (PMBCs) to Vim-deficient endothelial cells also
• in vivo, number of adherent leukocytes (bound to endothelial cells for >30 seconds) is significantly lower than in wild-type mice
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• velocity of rolling cells in mutants is 3 times higher than in wild-type
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cardiovascular system
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• endothelial-cell barrier integrity is compromised in Vim-deficient mice
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homeostasis/metabolism
hematopoietic system
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• homing of Vim-deficient lymphocytes is markedly reduced in vivo both in wild-type and Vim-null mice
• wild-type or Vim-deficient lymphocytes home more effectively to mesenteric lymph nodes and spleens of null mice than wild-type animals
|
|
• number of transmigrated leukocytes in Vim-deficient mice is significantly higher than in wild-type; transmigration efficiency of adherent cells is 2.6-fold higher than in wild-type mice
|
|
• adhesion of Vim-null leukocytes (PMBCs) to wild-type or Vim-deficient endothelial cells is markedly reduced; wild-type peripheral blood mononuclear cells (PMBCs) to Vim-deficient endothelial cells also
• in vivo, number of adherent leukocytes (bound to endothelial cells for >30 seconds) is significantly lower than in wild-type mice
|
|
• velocity of rolling cells in mutants is 3 times higher than in wild-type
|
