Analysis Tools
mortality/aging
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• induction of Cre by pI-pC administration leads to death within 10 days with a median survival time of 6 days after first injection of pI-pC
• lethally irradiated wild-type mice that receive mutant bone marrow die within 11 days of Cre induction in the bone marrow derived cells
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hematopoietic system
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• there is a profound reduction in the ability of CD4 and CD8 T cells to proliferate in response to mitogenic stimuli 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of nucleated cells in the bone marrow including stem and progenitor cells 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of granulocytes in the bone marrow 6 days after induction of Cre by pI-pC administration
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• mean RBC counts are reduced by more than half 6 days after induction of Cre by pI-pC administration
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• percentage of hematocrit is reduced by more than half 6 days after induction of Cre by pI-pC administration
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• hemoglobulin content is reduced by more than half 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of granulocytes in the bone marrow 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of B-cells in the bone marrow 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of hematopoietic progenitors in the bone marrow 6 days after induction of Cre by pI-pC administration
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immune system
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• there is a profound reduction in the ability of CD4 and CD8 T cells to proliferate in response to mitogenic stimuli 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of granulocytes in the bone marrow 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of B-cells in the bone marrow 6 days after induction of Cre by pI-pC administration
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cellular
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• there is a profound reduction in the ability of CD4 and CD8 T cells to proliferate in response to mitogenic stimuli 6 days after induction of Cre by pI-pC administration
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