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Phenotypes Associated with This Genotype
Genotype
MGI:3797396
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Dicer1tm1Mmk/Dicer1tm1Mmk
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S1/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (5 available); any Bcl2l11 mutation (37 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (26 available)
Dicer1tm1Mmk mutation (0 available); any Dicer1 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:135783 )
• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Bcl2l11tm1.1Ast/Bcl2l11+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice

hematopoietic system
decreased B cell number ( J:135783 )
• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Bcl2l11tm1.1Ast/Bcl2l11+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory