Phenotypes Associated with This Genotype

Genotype
MGI:3797393

• Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk; Cd79a^tm1(cre)Reth/Cd79a⁺
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased immature B cell number ( J:135783 )

• hardly detected

increased pro-B cell number ( J:135783 )

• in the bone marrow

arrested B cell differentiation ( J:135783 )

• B cell development is almost completely blocked at the pro- to pre-B cell transition

decreased mature B cell number ( J:135783 )

• hardly detected

decreased pre-B cell number ( J:135783 )

• in the bone marrow due to a massive increase in apoptosis

hematopoietic system

decreased immature B cell number ( J:135783 )

• hardly detected

increased pro-B cell number ( J:135783 )

• in the bone marrow

arrested B cell differentiation ( J:135783 )

• B cell development is almost completely blocked at the pro- to pre-B cell transition

decreased mature B cell number ( J:135783 )

• hardly detected

decreased pre-B cell number ( J:135783 )

• in the bone marrow due to a massive increase in apoptosis