Phenotypes Associated with This Genotype

Genotype
MGI:3797232

• Allelic Composition: Mapk1^tm2Moga/Mapk1^tm2Moga; Mapk3^tm1Gpg/Mapk3^tm1Gpg; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal pro-B cell morphology ( J:134528 )

• two weeks after Cre induction by pI-pC injection, the ratio of BP-1⁺HAS^high cells to BP-1⁺HAS^low cells is much lower than in controls indicating a defect in the transition from pro-B cells to pre-B cells

• there is a 6-fold reduction in the percentage of pro B cells in the bone marrow that are in the S phase

abnormal pro-B cell differentiation ( J:134528 )

• bone marrow from mutant mice that have had induction of Cre by pI-pC injection are unable to reconstitute the B cell compartment in irradiated alymphoid mice

• reconstitution still fails when pro B cells are encouraged to differentiate by injection of Igbeta antibodies into the host mice

decreased pre-B cell number ( J:134528 )

• two weeks after Cre induction by pI-pC injection, pre-B cell (B220^lowIgM^-Cd43^-) numbers in the bone marrow are 7% of controls

• immature B cells (B220^lowIgM⁺Cd43^-) in the bone marrow are also reduced by a similar amount

hematopoietic system

abnormal pro-B cell morphology ( J:134528 )

• two weeks after Cre induction by pI-pC injection, the ratio of BP-1⁺HAS^high cells to BP-1⁺HAS^low cells is much lower than in controls indicating a defect in the transition from pro-B cells to pre-B cells

• there is a 6-fold reduction in the percentage of pro B cells in the bone marrow that are in the S phase

abnormal pro-B cell differentiation ( J:134528 )

• bone marrow from mutant mice that have had induction of Cre by pI-pC injection are unable to reconstitute the B cell compartment in irradiated alymphoid mice

• reconstitution still fails when pro B cells are encouraged to differentiate by injection of Igbeta antibodies into the host mice

decreased pre-B cell number ( J:134528 )

• two weeks after Cre induction by pI-pC injection, pre-B cell (B220^lowIgM^-Cd43^-) numbers in the bone marrow are 7% of controls

• immature B cells (B220^lowIgM⁺Cd43^-) in the bone marrow are also reduced by a similar amount