Mouse Genome Informatics
hm
    Vldlrtm1Her/Vldlrtm1Her
B6;129S7-Vldlrtm1Her/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• CNV membranes develop after 6 months of age with some tissue destruction in INL and ONL
• some retinal-choroidal anastomoses may be observed at 10 months
• accumulation of cell debris is observed prior to development of intraretinal neovascularization (J:128315)
• angiomatous growths are densely distributed throughout retina at 4 weeks (J:132497)
• at 6 weeks, scattered pink spots progress to large, irregular pink areas by 6 months; leaking spots decrease after 8 months with large rigid vascular tangles still present and leakage is barely detectable by 12 months (J:132497)
• fibrosis formation is present at 12 months, beginning around 3 months with fibroblast accumulation at lesion site (J:132497)
• new vessels form in outer plexiform layer of retina around 3 weeks of age; vessels migrate into subretinal space by 4 weeks (J:128315)
• angiography shows leakage in retinas at 6 weeks, mainly in central area of retina near optic nerve, with red blood cells found around the leakage spot; neovascularization is localized to outer nuclear layer and in subretinal space (J:128315)
• signs of new vessel growth is observed at 14 days in deep capillary bed of outer plexiform layer (OPL) of retina, protruding into avascular zone of outer nuclear layer (ONL) (J:132497)
• new vessel buds reach subretinal space by P15 (J:132497)
• leakage is first seen at 3 weeks and increases with age, with leaking areas covering most of retinal by 6 weeks (J:132497)
• clumps of retinal pigmented epithelial cells (RPE) adhere to neovascular tufts in subretinal space; these increase with age (J:132497)
• subretinal neovascularization (SRN) is seen at 6 weeks of age (J:132497)
• fibrosis formation is present at 12 months, beginning around 3 months with fibroblast accumulation at lesion site (J:132497)
• thickening of RPE cells is observed prior to development of intraretinal neovascularization (J:128315)
• disruption of RPE layer is observed by 6 weeks of age (J:132497)
• pigment adhesions to neural tissue are seen by 6 weeks, representing pigment epithelium detachment (J:132497)
• between 6 and 8 weeks, both outer and inner segments are disrupted in lesion area; migration of RPE cells into lesion area is observed
• significant loss of photoreceptors is seen at 6 months, resulting in thinning of outer nuclear layer (J:128315)
• increased loss is detected at 12 months (J:132497)
• observed at 10 months
• reduced in thickness by 6 months (J:128315)
• reduced overall at 12 months; layer is completely diminished by 24 months (J:132497)
• destruction of ONL is seen starting at 6 months

nervous system
• significant loss of photoreceptors is seen at 6 months, resulting in thinning of outer nuclear layer (J:128315)
• increased loss is detected at 12 months (J:132497)
• observed at 10 months

cardiovascular system
• CNV membranes develop after 6 months of age with some tissue destruction in INL and ONL
• some retinal-choroidal anastomoses may be observed at 10 months
• new vessels form in outer plexiform layer of retina around 3 weeks of age; vessels migrate into subretinal space by 4 weeks (J:128315)
• angiography shows leakage in retinas at 6 weeks, mainly in central area of retina near optic nerve, with red blood cells found around the leakage spot; neovascularization is localized to outer nuclear layer and in subretinal space (J:128315)
• signs of new vessel growth is observed at 14 days in deep capillary bed of outer plexiform layer (OPL) of retina, protruding into avascular zone of outer nuclear layer (ONL) (J:132497)
• new vessel buds reach subretinal space by P15 (J:132497)
• leakage is first seen at 3 weeks and increases with age, with leaking areas covering most of retinal by 6 weeks (J:132497)
• clumps of retinal pigmented epithelial cells (RPE) adhere to neovascular tufts in subretinal space; these increase with age (J:132497)
• subretinal neovascularization (SRN) is seen at 6 weeks of age (J:132497)
• fibrosis formation is present at 12 months, beginning around 3 months with fibroblast accumulation at lesion site (J:132497)

pigmentation
• thickening of RPE cells is observed prior to development of intraretinal neovascularization (J:128315)
• disruption of RPE layer is observed by 6 weeks of age (J:132497)
• pigment adhesions to neural tissue are seen by 6 weeks, representing pigment epithelium detachment (J:132497)

Mouse Models of Human Disease
OMIM IDRef(s)
Macular Degeneration, Age-Related, 1; ARMD1 603075 J:132497