Analysis Tools
immune system
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• monocyte recruitment and differentiation in the lungs is increased compared to in wild-type mice
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• 12-fold in the lungs at 7 weeks
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• the number of circulating monocytes is 2-fold higher than in wild-type mice
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• 2.6-fold in the lungs at 7 weeks
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• 1.7-fold in the lungs at 7 weeks
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• 1.7-fold in the lungs at 7 weeks
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• 1.3-fold in the lungs at 7 weeks
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• the number of circulating monocytes is 2-fold higher than in wild-type mice
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• at 7 weeks, macrophages in the lungs are larger in size than wild-type and exhibit severe lipid accumulation unlike in wild-type lungs
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• mice exhibit increased secretion of TNF-alpha, IL-1beta, and IL-12 compared to wild-type mice
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• mice exhibit increased secretion of MIP-1alpha, MIP-2 and MCP-1 compared to wild-type mice
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• at 7 weeks, mice exhibit increased cytokine levels in bronchialveolar lavage fluid (BAL)
• alveolar macrophage cell supernatant contains increased levels of IL-6, IL-1beta, IL-1alpha, IL-12 and KC with decreased levels of IL-10
• however, alveolar macrophage cell numbers, and plasma levels of chemokine other than KC and cytokine are normal
• BAL fluid exhibits increased numbers of CD8+ and CD4+ T cells, B cells, eosinophils, neutrophils and dendritic cells compared to in wild-type BAL fluid
• reconstitution of mice with wild-type bone marrow increased macrophage accumulation but decrease neutrophil, dendritic cell, and eosinophil accumulation while reconstitution wild-type mice with mutant bone marrow decreased macrophage accumulation but increased neutrophil, dendritic cells and eosinophil accumulation
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respiratory system
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• at 7 weeks, mice exhibit increased cytokine levels in bronchialveolar lavage fluid (BAL)
• alveolar macrophage cell supernatant contains increased levels of IL-6, IL-1beta, IL-1alpha, IL-12 and KC with decreased levels of IL-10
• however, alveolar macrophage cell numbers, and plasma levels of chemokine other than KC and cytokine are normal
• BAL fluid exhibits increased numbers of CD8+ and CD4+ T cells, B cells, eosinophils, neutrophils and dendritic cells compared to in wild-type BAL fluid
• reconstitution of mice with wild-type bone marrow increased macrophage accumulation but decrease neutrophil, dendritic cell, and eosinophil accumulation while reconstitution wild-type mice with mutant bone marrow decreased macrophage accumulation but increased neutrophil, dendritic cells and eosinophil accumulation
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• at 3 weeks of age mice exhibit an accumulation of lipids at the edge of the lung lobe and by 8 months exhibit a severe accumulation of lipid in all parts of the lung unlike wild-type mice
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• at 8 months, mice exhibit enlargement of the alveoli unlike in wild-type mice
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• at 7 weeks of age mice exhibit an increase in surfactant D in the lungs
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homeostasis/metabolism
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• at 3 weeks of age mice exhibit an accumulation of lipids at the edge of the lung lobe and by 8 months exhibit a severe accumulation of lipid in all parts of the lung unlike wild-type mice
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cellular
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• monocyte recruitment and differentiation in the lungs is increased compared to in wild-type mice
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hematopoietic system
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• monocyte recruitment and differentiation in the lungs is increased compared to in wild-type mice
|
|
• 12-fold in the lungs at 7 weeks
|
|
• the number of circulating monocytes is 2-fold higher than in wild-type mice
|
|
• 2.6-fold in the lungs at 7 weeks
|
|
• 1.7-fold in the lungs at 7 weeks
|
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• 1.7-fold in the lungs at 7 weeks
|
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• 1.3-fold in the lungs at 7 weeks
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• the number of circulating monocytes is 2-fold higher than in wild-type mice
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• at 7 weeks, macrophages in the lungs are larger in size than wild-type and exhibit severe lipid accumulation unlike in wild-type lungs
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