Phenotypes Associated with This Genotype

Genotype
MGI:3796169

• Allelic Composition: Robo4^tm1Kzh/Robo4^tm1Kzh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular development ( J:208012 )

• E15.5 diaphragms show slightly disrupted vascular development in the diaphragm

abnormal angiogenesis ( J:133680 )

• in vitro tube formation by endothelial cells in response to VEGF fails to stop in response to SLIT2

decreased angiogenesis ( J:208012 )

• SLIT3-induced angiogenesis is greatly diminished in cornea micropocket experiments

abnormal vascular permeability ( J:133680 )

• retinal endothelium has a higher basal permability than wild-type mice

• mice are refractory to SLIT2 or SLIT3 prevention of vascular leakiness of the retina caused by VEGF administration into the vitreous of the eye

pathological neovascularization ( J:133680 )

• retinopathy caused by exposure to hypoxic followed by hyperoxic conditions is more severe in these mice with a third more neovascularization occuring

• this retinopathy is refactory to SLIT2 treatment

respiratory system

abnormal lung endothelial cell migration ( J:133680 )

• lung endothelial cells fail to stop migrating up a VEGF gradient in response to SLIT-2

cellular

abnormal lung endothelial cell migration ( J:133680 )

• lung endothelial cells fail to stop migrating up a VEGF gradient in response to SLIT-2

homeostasis/metabolism

impaired skin barrier function ( J:133680 )

• mice are refractory to SLIT2 prevention of endothelial leakiness caused by VEGF administration into the skin

integument

impaired skin barrier function ( J:133680 )

• mice are refractory to SLIT2 prevention of endothelial leakiness caused by VEGF administration into the skin

muscle

abnormal diaphragm morphology ( J:208012 )

• E15.5 diaphragms show slightly disrupted vascular development in the diaphragm