Analysis Tools
mortality/aging
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• mean male death occurs at 40 days with signs of distress appearing 12 to 24 hours prior to death
• lethality is not background dependent and is observed in mice crossed to Mus castaneus, C57BL/6J and BXH2
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reproductive system
| N |
• male mice that survive long enough to reproduce are fertile
|
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• moribund male mice exhibit underdeveloped seminal vesicles
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liver/biliary system
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• moribund male mice exhibit slightly enlarged livers unlike in wild-type mice
|
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• moribund male mice exhibit microvesicular steatosis unlike in wild-type mice
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pale liver
(
J:79618
)
|
• moribund male mice exhibit salmon-colored liver with small, pale granules dispersed throughout the organ unlike in wild-type mice
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respiratory system
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• in male mice just prior to death
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growth/size/body
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• peripubescent male mice are smaller than normal
|
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• moribund male mice exhibit slightly enlarged livers unlike in wild-type mice
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adipose tissue
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• moribund male mice exhibit underdeveloped fat pads surrounding the seminal vesicles
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behavior/neurological
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• just prior to death, male mice exhibit extreme lethargy unlike in wild-type mice
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cardiovascular system
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• just prior to death, male mice exhibit prominent blood vasculature of the extremities unlike in wild-type mice
|
endocrine/exocrine glands
|
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• moribund male mice exhibit underdeveloped seminal vesicles
|
integument
|
• just prior to death, male mice exhibit scruffy fur unlike in wild-type mice
|
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• just prior to death, male mice exhibit pinkish or purplish skin color unlike in wild-type mice
|
