Phenotypes Associated with This Genotype

Genotype
MGI:3795856

• Allelic Composition: Gli2^tm1Alj/Gli2^tm1Alj; Ptch1^tm1Mps/Ptch1^tm1Mps
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:79392 )

• some embryos survive to E10.5; at E11.5, no embryos are recovered

nervous system

nervous system phenotype ( J:79392 )

N

abnormal brain development ( J:79392 )

• at E10.5 dorsal brain has not closed

exencephaly ( J:79392 )

• embryos found at E10.5 exhibit exencephaly

abnormal spinal cord morphology ( J:79392 )

• only small number of V3 interneurons remain in ventral midline of spinal cord at E9.5

increased motor neuron number ( J:79392 )

• more motor neurons are generated than in Gli2-null mutants; motor neuron population expands into dorsal half of spinal cord

abnormal ventral interneuron 3 morphology ( J:79392 )

• number of V3 interneurons is reduced compared to Ptc-null embryos at E9.5