Phenotypes Associated with This Genotype

Genotype
MGI:3795472

• Allelic Composition: Ebi3^Gt716Lex/Ebi3^Gt716Lex; Tg(DO11.10)10Dlo/0
• Genetic Background: involves: 129S5/SvEvBrd * BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:134148 )

• following anti-CD3 antibody stimulation, differentiation into Th17 cells is increased compared to in wild-type mice

abnormal circulating interleukin level ( J:134148 )

• following ovalbumin stimulation or infection with Listeriosis monocytogenes, Il-22 plasma levels are increased compared to in wild-type mice

increased circulating interleukin-17 level ( J:134148 )

• following ovalbumin stimulation or infection with Listeriosis monocytogenes

increased interleukin-17 secretion ( J:134148 )

• following anti-CD3 antibody stimulation

decreased susceptibility to bacterial infection ( J:134148 )

• mice are resistant to infection with Listeriosis monocytogenes with a 45-fold less bacteria load in the spleen and a 150-fold less bacterial load in the liver after re-challenge compared to in similarly treated wild-type mice

homeostasis/metabolism

abnormal circulating interleukin level ( J:134148 )

• following ovalbumin stimulation or infection with Listeriosis monocytogenes, Il-22 plasma levels are increased compared to in wild-type mice

increased circulating interleukin-17 level ( J:134148 )

• following ovalbumin stimulation or infection with Listeriosis monocytogenes

hematopoietic system

abnormal T cell differentiation ( J:134148 )

• following anti-CD3 antibody stimulation, differentiation into Th17 cells is increased compared to in wild-type mice