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Phenotypes Associated with This Genotype
Genotype
MGI:3795284
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Rspo1tm1Mcch/Rspo1tm1Mcch
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (47 available)
Rspo1tm1Mcch mutation (0 available); any Rspo1 mutation (21 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:133933 )
• majority of embryos die during early embryonic development due to extensive Beta-catenin activation

reproductive system
reproductive system phenotype ( J:133933 )
N
• female mice that survive to birth have a normal reproductive system without the masculinazation of genitalia normally associated with Rspo1 null mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory