Phenotypes Associated with This Genotype

Genotype
MGI:3795183

• Allelic Composition: a/a; Tyrp1^B-lt/Tyrp1^B-lt
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal dorsoventral coat patterning ( J:13094 )

• the ventral hairs are substantially less pigmented than those of the dorsum

abnormal hair follicle melanin granule morphology ( J:13094 )

• although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found

• by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes

enlarged hair follicle melanin granules ( J:13094 )

abnormal hair shaft melanin granule morphology ( J:13094 )

• variation in the amount of pigmentation present in one hair shaft versus the next

• variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft

abnormal hair shaft melanin granule distribution ( J:13094 )

• hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions

• decreased pigmentation in the hair shafts with age

reduced hair shaft melanin granule number ( J:13094 )

integument

abnormal dorsoventral coat patterning ( J:13094 )

• the ventral hairs are substantially less pigmented than those of the dorsum

abnormal hair follicle melanin granule morphology ( J:13094 )

• although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found

• by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes

enlarged hair follicle melanin granules ( J:13094 )

abnormal hair shaft melanin granule morphology ( J:13094 )

• variation in the amount of pigmentation present in one hair shaft versus the next

• variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft

abnormal hair shaft melanin granule distribution ( J:13094 )

• hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions

• decreased pigmentation in the hair shafts with age

reduced hair shaft melanin granule number ( J:13094 )