Phenotypes Associated with This Genotype

Genotype
MGI:3795122

• Allelic Composition: Axin1^Fu-ki/Axin1^Fu-ki
• Genetic Background: involves: Bagg albino * CF * fancier's mice

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:13017 )

• most homozygotes are still alive at embryonic day 9, but the majority are dead by day 10 and all are dead by day 12

embryo

rostral-caudal axis duplication ( J:13017 )

• instances are found of complete or partial duplication of the entire embryonic axis, or of individual organs such as the heart, or extraneous growth of a lump of tissue, or doubled neural folds

embryonic growth retardation ( J:13017 )

• seen in day 8 embryos

abnormal embryonic tissue morphology ( J:13017 )

• 8 day embryos can have hyperplasia of neuroectoderm and mesenchyme yielding folds protruding into the amniotic cavity, 9 day embryos frequently have more contorted headfolds and neural folds

split notochord ( J:13017 )

small tail bud ( J:13017 )

• 9 day embryos have abnormally small tail buds

disorganized embryonic tissue ( J:13017 )

abnormal extraembryonic tissue morphology ( J:13017 )

• 8 and 9 day embryos frequently have abnormal embryonic membranes and some embryos are found outside of the yolk sac

abnormal allantois morphology ( J:13017 )

• instances of multiple allantoides are found

growth/size/body

embryonic growth retardation ( J:13017 )

• seen in day 8 embryos

limbs/digits/tail

small tail bud ( J:13017 )

• 9 day embryos have abnormally small tail buds