Mouse Genome Informatics
tg
    Tg(MMTV-TGFBR2)7Hlm/Tg(MMTV-TGFBR2)7Hlm
involves: C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• there is consistent retardation of involution observed in mice both 7 and 10 days after weaning compared to control mice (J:85799)
• there is accelerated development and differentiation of mammary epithelial cells during early to mid-pregnancy but impaired development during the last stages of pregnancy (J:85799)
• the hyperplasia observed is more severe than observed in mice hemizyguos for the transgene (J:46432)
• alveolar hyperplasia is evident in non-pregnant females while no alveolar structures are observed in non-pregnant wild-type mice (J:46432)
• the alveolar-like buds fill in the spaces between the ductal structure of the mammary gland (J:46432)
• the morphology of the mammary gland resembles the morphology found in pregnant wild-type mice at early to mid-gestation (J:46432)
• mice 15 days into their first pregnancy have more prominent vacuoles in the alveoli than in control mice (J:85799)
• the alveolar are also in a more differentiated state as indicated by the presence of milk proteins in the lumen (J:85799)
• mice have fewer alveoli 1 day after the onset of lactation than do control mice (J:85799)
• the milk protein beta-Casein is detectable in the alveolar buds of non-pregnant females (J:46432)
• the concentration and location of the beta-Casein is similar to what is found in 12.5-day pregnant females (J:46432)
• mice are frequently unable to feed their pups (J:85799)
• while alveolar hyperplasia with some milk production occurs early in pregnancy (15 days), the mammary glands fail to develop into fully functional organs as indicated by less extensive alveolar development and decreased milk production compared to non-transgenic controls (J:85799)

tumorigenesis
• mice that have experienced two rounds of pregnancy have a frequency of spontaneous mammary carcinoma
• 47% of these females develop mammary tumors with a median latency of 27.5 months
• 72% of these tumors are high grade mammary intraepithelial neoplasias
• the remaining 28% are invasive adenocarcinomas or adenosquamous carcinomas

integument
• there is consistent retardation of involution observed in mice both 7 and 10 days after weaning compared to control mice (J:85799)
• there is accelerated development and differentiation of mammary epithelial cells during early to mid-pregnancy but impaired development during the last stages of pregnancy (J:85799)
• alveolar hyperplasia is evident in non-pregnant females while no alveolar structures are observed in non-pregnant wild-type mice (J:46432)
• the alveolar-like buds fill in the spaces between the ductal structure of the mammary gland (J:46432)
• the morphology of the mammary gland resembles the morphology found in pregnant wild-type mice at early to mid-gestation (J:46432)
• the hyperplasia observed is more severe than observed in mice hemizyguos for the transgene (J:46432)
• mice 15 days into their first pregnancy have more prominent vacuoles in the alveoli than in control mice (J:85799)
• the alveolar are also in a more differentiated state as indicated by the presence of milk proteins in the lumen (J:85799)
• mice have fewer alveoli 1 day after the onset of lactation than do control mice (J:85799)
• the milk protein beta-Casein is detectable in the alveolar buds of non-pregnant females (J:46432)
• the concentration and location of the beta-Casein is similar to what is found in 12.5-day pregnant females (J:46432)
• mice are frequently unable to feed their pups (J:85799)
• while alveolar hyperplasia with some milk production occurs early in pregnancy (15 days), the mammary glands fail to develop into fully functional organs as indicated by less extensive alveolar development and decreased milk production compared to non-transgenic controls (J:85799)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:85799