Phenotypes Associated with This Genotype

Genotype
MGI:3794971

• Allelic Composition: Tg(MMTV-TGFBR2)7Hlm/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:46432 )

♀ • alveolar hyperplasia is evident in non-pregnant females while no alveolar structures are observed in non-pregnant wild-type mice

♀ • the alveolar-like buds fill in the spaces between the ductal structure of the mammary gland

♀ • the morphology of the mammary gland resembles the morphology found in pregnant wild-type mice at early to mid-gestation

♀ • the hyperplasia observed is less severe than observed in mice homozygous for the transgene

abnormal lactation ( J:46432 )

♀ • the milk protein beta-Casein is detectable in the alveolar buds of non-pregnant females

integument

mammary gland alveolar hyperplasia ( J:46432 )

♀ • alveolar hyperplasia is evident in non-pregnant females while no alveolar structures are observed in non-pregnant wild-type mice

♀ • the alveolar-like buds fill in the spaces between the ductal structure of the mammary gland

♀ • the morphology of the mammary gland resembles the morphology found in pregnant wild-type mice at early to mid-gestation

♀ • the hyperplasia observed is less severe than observed in mice homozygous for the transgene

abnormal lactation ( J:46432 )

♀ • the milk protein beta-Casein is detectable in the alveolar buds of non-pregnant females