Phenotypes Associated with This Genotype

Genotype
MGI:3794860

• Allelic Composition: Camk4^tm1Tch/Camk4^tm1Tch
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:64210 )

N • mice exhibit normal neuroanatomy

abnormal Purkinje cell dendrite morphology ( J:64210 )

• Purkinje neuron dendritic arbors appear reduced compared to wild-type neurons in culture

abnormal excitatory postsynaptic currents ( J:64210 )

• the R input is increased by 250% compared to in wild-type mice

decreased excitatory postsynaptic current frequency ( J:64210 )

• the frequency of miniature excitatory postsynaptic currents is reduced by 70%

reduced long-term depression ( J:64210 )

• long term depression is impaired

behavior/neurological

behavior/neurological phenotype ( J:64210 )

N • mice exhibit normal spatial memory

abnormal locomotor activation ( J:64210 )

• while locomotion and sensorimotor functions are normal, mice take longer to initiate movement compared to wild-type mice