Phenotypes Associated with This Genotype

Genotype
MGI:3794771

• Allelic Composition: Nos2^tm1Lau/Nos2^tm1Lau
• Genetic Background: B6.129P2-Nos2^tm1Lau/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal surfactant physiology ( J:130520 )

• following infection with mycoplasma, the numbers of large surfactant aggregates is decreased and higher protein to lipid ratios are present in the bronchoalveolare lavage fluid compared to similarly infected wild-type mice

• following infection with mycoplasma, the minimal surface area on the pulsating bubble is increased and the levels of surfactant protein are decreased compared to similarly infected wild-type mice

behavior/neurological

abnormal sleep pattern ( J:83571 )

• mice spend more time in REM sleep during the light phase as a result of an increased number of REM episodes and shortened duration of the inter REM intervals

• mice spend less time in non-REM sleep during the dark phase

• during the light phase mice spend the same amount of time in non-REM sleep but have a higher number of non-REM episodes of shorter average duration

abnormal circadian sleep/wake cycle ( J:83571 )

• mice display a more pronounced diurnal variation of sleep-wake activity

nervous system

abnormal brain wave pattern ( J:83571 )

• during non-REM sleep the absolute value of slow wave activity is increased

immune system

abnormal inflammatory response ( J:103018 )

• unlike in wild-type mice, LPS injection fails to reduce nighttime body temperature relative to saline injected controls

decreased inflammatory response ( J:103018 )

• fever in response to LPS injection is partially reduced compared to wild-type controls

• the fever response to LPS is initiated but not sustained

• however, fever in response to turpentine injection is not different from controls