Phenotypes Associated with This Genotype

Genotype
MGI:3794533

• Allelic Composition: Krd/Krd⁺
• Genetic Background: involves: C3H/He * C57BL/6 * YBR/Ki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:20807 )

• Background Sensitivity: the expected 50% transgenic offspring are observed at weaning when the founder mice are crossed with C57BL/6

• Background Sensitivity: the percentage of transgenic offspring fall in subsequent backcrosses to C57BL/6 with 35% being transgenic in the 2^nd backcross, 19% being transgenic in the 3^rd backcross, and 11% being transgenic in the 4^th

• Background Sensitivity: lethality in the backcrosses to C57BL/6 occurs in the late fetal or early postnatal stage with at least some of the mice dying from kidney aplasia

• Background Sensitivity: percentages of transgenic offspring are closer to expected rates when founder mice are crossed with C3H/HeJ mice with 46% being transgenic in the 2^nd backcross and 42% being transgenic in the 3^rd backcross

growth/size/body

slow postnatal weight gain ( J:20807 )

• the growth of these mice is retarded for the first 2 months of birth being about 80% of littermate controls

• normal weight is eventually reached

kidney cyst ( J:20807 )

• unilateral kidney cysts are common in these mice

renal/urinary system

kidney cyst ( J:20807 )

• unilateral kidney cysts are common in these mice

kidney cortex hypoplasia ( J:20807 )

• the thickness of the cortical tissue is decreased due in part to less numbers of glomeruli and a smaller profile of proximal convoluted tubules

abnormal kidney corticomedullary boundary morphology ( J:20807 )

• immature mesenchymal tissue is more prominent at the corticomedullary junction

abnormal nephrogenic zone morphology ( J:20807 )

• the nephrogenic zone is attenuated and disorganized

delayed kidney development ( J:20807 )

• kidneys from these mice demonstrate considerable immaturity compared with wild-type mice

• the nephrogenic zone is attenuated and disorganized

• the thickness of the cortical tissue is decreased due in part to less numbers of glomeruli and a smaller profile of proximal convoluted tubules

• immature mesenchymal tissue is more prominent at the corticomedullary junction

• these immature features are still present at a lesser degree in mice 4 days old but disappear by adulthood

decreased kidney weight ( J:20807 )

• kidneys with no obvious defects weigh significantly less with a mean of 4.8 mg/g bodyweight compared to 6.2 mg/g for kidneys from littermate controls

decreased nephron number ( J:20807 )

• the number of mature nephrons is smaller

absent kidney ( J:20807 )

• kidneys were absent in one stillborn pup that occurred among 24 observed births

single kidney ( J:20807 )

• only one kidney is present in 13% of mice

dilated ureter ( J:20807 )

• is commonly observed

vision/eye

abnormal retina layer morphology ( J:20807 )

• retinas of some mice are noticeably thinner than controls, with extreme hypocellularity occurring in different positions in the retina

thin retina inner nuclear layer ( J:20807 )

• the nuclear layers are thinner with fewer somata present than in controls

thin retina outer nuclear layer ( J:20807 )

• the nuclear layers are thinner with fewer somata present than in controls

disorganized retina layers ( J:20807 )

• all mice contain malformations of the retina

• these malformations differed between animals but include zones of narrowing, an excess of somota in a single nuclear layer, photoreceptor nuclei lying ectopically within the photoreceptor layer, and rosettes of photoreceptors enclosed between retinal layers

abnormal eye electrophysiology ( J:20807 )

• the electroretinograms of eight mice varied from three in low normal range to three that are extremely abnormal

• both a- and b- waves are abnormal in mice in affected mice