Phenotypes Associated with This Genotype

Genotype
MGI:3793710

• Allelic Composition: Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:134826 )

• mice are more sensitive to dopamine neuron loss induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) than wild-type mice

behavior/neurological

abnormal motor coordination/balance ( J:134826 )

• despite normal stride lengths, inverted grid performance and wall time, mice exhibit an increase in the average number of forepaw faults compared to wild-type mice

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:134826 )

• mice are more sensitive to dopamine neuron loss induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) than wild-type mice

abnormal dopamine level ( J:134826 )

• in mice 3 to 4 months old, dopamine transporter uptake is increased 29% compared to in wild-type mice

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:134826 )

• mice are more sensitive to dopamine neuron loss induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) than wild-type mice