Analysis Tools
mortality/aging
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• lethality is seen between 3 and 20 weeks of age
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• only 38% of the expected number of mice are present at weaning
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• only 46% of the expected number of embryos are present at E18.5
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growth/size/body
skeleton
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• small extra bone present above C1 in 38% of double homozygous mice
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• transformation of T7 to T8 and T13 to L1 are seen in 62% and 100% of double homozygous mice, respectively
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• transformation of C1 to C2, C5 to C6, and C7 to T1 are seen in 92%, 23%, and 8% of double homozygous mice, respectively
• partial transformation of C7 to T1 is seen in 85% of double homozygous mice
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• transformation of L6 to S1 is seen in 100% of double homozygous mice
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hematopoietic system
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• shift in the distribution of myeloid to B lymphoid cells resulting in an increased percentage of myeloid cells
• within the B cell population, loss of immature B cells is greater than the loss of mature B cells
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• decreased number of hematopoietic cells in the thymus, bone marrow and spleen
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cellular
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• impaired ability of serum-starved MEFs to re-enter the cell cycle
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• defect in asynchronous proliferation in MEFs
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• in MEFs
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behavior/neurological
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• similar to that seen in mice homozygous for Bmi1tm1Brn alone at 2 months of age
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nervous system
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• all three layers are affected
• hypoplasia is similar to that in mice homozygous for Bmi1tm1Brn alone
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immune system
