Phenotypes for Gfap Vim MGI:3790659 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gfap^tm4Ito/Gfap^tm4Ito Vim^tm1Cba/Vim^tm1Cba
Genetic Background	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfap^tm4Ito mutation (1 available); any Gfap mutation (46 available)
Vim^tm1Cba mutation (2 available); any Vim mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal CNS glial cell morphology ( J:78341 )

• decreased glial fibrillary acidic protein (GFAP) immunoreactivity is more severe than in Gfap-single mutants

abnormal astrocyte morphology ( J:78341 )

• cultured E18.5 neurons have glial fibrillary acidic protein-immunoreactive filaments in astrocytes are sparse, irregularly arrayed, and sometimes disrupted

• dot-like aggregate structures appear in cultured E18.5 astrocytes

cellular

abnormal CNS glial cell morphology ( J:78341 )

• decreased glial fibrillary acidic protein (GFAP) immunoreactivity is more severe than in Gfap-single mutants

abnormal astrocyte morphology ( J:78341 )

• cultured E18.5 neurons have glial fibrillary acidic protein-immunoreactive filaments in astrocytes are sparse, irregularly arrayed, and sometimes disrupted

• dot-like aggregate structures appear in cultured E18.5 astrocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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