Phenotypes Associated with This Genotype

Genotype
MGI:3789956

• Allelic Composition: Cry1^tm1Asn/Cry1^tm1Asn; Cry2^tm1Hnos/Cry2^tm1Hnos
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal circadian behavior ( J:134129 )

• absence of diurnal changes in activity when kept in constant darkness

nervous system

abnormal baroreceptor physiology ( J:134129 )

• enhanced spontaneous and induced baroreflex sensitivity and loss of diurnal oscillations in spontaneous and induced baroflex sensitivity under constant dark conditions

cardiovascular system

abnormal circadian regulation of systemic arterial blood pressure ( J:134129 )

• absence of diurnal changes in mean arterial pressure and baroflex sensitivity when kept in constant darkness

abnormal circadian regulation of heart rate ( J:134129 )

abnormal vasoconstriction ( J:134129 )

• absence of an increase in mean arterial pressure in response to injection of 10ug/kg phenylephrine and only a small increase in response to injections of higher concentration

growth/size/body

decreased body weight ( J:134129 )

muscle

abnormal vasoconstriction ( J:134129 )

• absence of an increase in mean arterial pressure in response to injection of 10ug/kg phenylephrine and only a small increase in response to injections of higher concentration