Phenotypes Associated with This Genotype

Genotype
MGI:3789850

• Allelic Composition: Foxp2^tm1Momo/Foxp2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Motor and ultrasonic vocalization impairment in Foxp2^tm1Momo/Foxp2^tm1Momo and Foxp2^tm1Momo/Foxp2⁺ mice

behavior/neurological

abnormal vocalization ( J:132813 )

• at P10, heterozygous pups show a modest impairment of ultrasonic vocalization when separated from mothers

• heterozygous pups produce three vocalizations, including whistle-type vocalizations similar to wild-type vocalizations, as well as short-length and click-type sonic vocalizations that are not normally seen in wild-type

growth/size/body

decreased body weight ( J:132813 )

• homozygotes show a 10-15% reduction in weight by P10