Phenotypes Associated with This Genotype

Genotype
MGI:3789482

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ldlr^tm1Her/Ldlr^tm1Her
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:95598 )

• two out of 8 hypoxic hearts show thrombosis as well as atherosclerotic plaques

abnormal impulse conducting system conduction ( J:95598 )

abnormal ST segment ( J:95598 )

• elevated STU segment as a result of induced hypoxia

• noticeable at 16% oxygen concentration

• ECG is corrected by 10 minutes after restoration of normal oxygen

• hypoxia response unaffected by treatment with a thrombin inhibitor

abnormal response to cardiac infarction ( J:95598 )

• mice treated with a thrombin inhibitor display lower Troponin-T levels and fewer fibrinogen + cells than untreated mice 48 hours after hypoxia

decreased myocardial infarct size ( J:95598 )

• in mice treated with a thrombin inhibitor 48 hours after hypoxia

• infarctions are irregular in shape and subendocardial or intramural

homeostasis/metabolism

abnormal response to cardiac infarction ( J:95598 )

• mice treated with a thrombin inhibitor display lower Troponin-T levels and fewer fibrinogen + cells than untreated mice 48 hours after hypoxia

decreased myocardial infarct size ( J:95598 )

• in mice treated with a thrombin inhibitor 48 hours after hypoxia

• infarctions are irregular in shape and subendocardial or intramural

decreased circulating troponin level ( J:95598 )

• mice treated with a thrombin inhibitor display lower Troponin-T levels and fewer fibrinogen + cells than untreated mice 48 hours after hypoxia

abnormal thrombosis ( J:95598 )

nervous system

abnormal synapse morphology ( J:43043 )

• elevated cholesterol in the exofacial leaflet of the synaptic plasma membrane but not so high as for Ldlr deficient mice with normal Apoe alleles

• cholesterol levels in the cytofacial leaflet are reduced

• cholesterol/phospholipid ratio in the synaptic plasma membrane is elevated but not so much as for Ldlr deficient mice with normal Apoe alleles