Phenotypes for Apoe Lgals3 MGI:3789127 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Lgals3^tm1Poi/Lgals3^tm1Poi
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (34 available); any Apoe mutation (163 available)
Lgals3^tm1Poi mutation (4 available); any Lgals3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:130923 )

• at 25 to 31 weeks of age, mice exhibit a lower number inflammatory infiltrate and mast cells in adventitia than Apoe^tm1Unc homozygotes

• at 36 to 44 months of age, mice exhibit fewer atherosclerotic lesions and atheromatous plaques compared to in Apoe^tm1Unc homozygotes and do not exhibit an age-related increase in lesion number, athlerosclerotic microaneurysms or periaortic vascular channels that are evident in Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased circulating cholesterol level ( J:130923 )

• compared to in Lgals3^tm1Poi homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24