Mouse Genome Informatics
tg
    Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0
involves: C57BL/6 * C57BL/6NTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• in forced-swim test, adult mice treated with tamoxifen at P7 display depressive-like behavior as demonstrated by shorter latencies between floating episodes than those of control mice
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult controls
• adult mice injected with tamoxifen at P7 show deficits in spatial working memory in a working memory test (delayed nonmatched to place task, DNMTP) compared to adult controls (wild-type and vehicle-treated transgenic animals)
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult wild-type
• in a social choice paradigm, adult mice treated with tamoxifen at P7 spend significantly more time in empty chamber away from stimulus mouse than in stimulus mouse chamber compared to controls
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult controls

nervous system
• reduced dendritic complexity in adult mice treated with tamoxifen at P7
• numbers of branch points and intersections in hippocampal neurons in adult mice treated with tamoxifen at P7 are reduced compared to controls;
• adult mice treated with tamoxifen at P7 show reduced hippocampal synaptic input/output function compared to controls
• paired pulse facilitation and long term potentiation in mice treated at P7 are both normal indicating that presynaptic function and LTP are unaffected by transgenic protein expression

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:127235