Phenotypes for Lep Tg(Pmch-ATXN3*)3Rck MGI:3785732 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lep^ob/Lep^ob Tg(Pmch-ATXN3*)3Rck/0
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)
Tg(Pmch-ATXN3*)3Rck mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:104264 )

• at 24-28 weeks, weight is significantly reduced compared to Lep^ob homozygotes

homeostasis/metabolism

decreased circulating glucose level ( J:104264 )

• plasma glucose concentration is significantly reduced compared to Lep^ob homozygotes

behavior/neurological

abnormal maternal nurturing ( J:104264 )

• females can not nurture pups through weaning age; no data is provided

reproductive system

abnormal fertility/fecundity ( J:104264 )

• improvement in fertility is observed; normal-sized litters are produced; no data is provided

liver/biliary system

liver/biliary system phenotype ( J:104264 )

N	• steatosis observed in Lep^ob homozygotes is normalized in double mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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