Phenotypes for Fgr Hck Lyn MGI:3785296 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fgr^tm1Hev/Fgr^tm1Hev Hck^tm1Hev/Hck^tm1Hev Lyn^tm1Sor/Lyn^tm1Sor
Genetic Background	B6.Cg-Hck^tm1Hev Fgr^tm1Hev Lyn^tm1Sor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgr^tm1Hev mutation (0 available); any Fgr mutation (132 available)
Hck^tm1Hev mutation (0 available); any Hck mutation (29 available)
Lyn^tm1Sor mutation (2 available); any Lyn mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal neutrophil physiology ( J:113463 )

• neutrophil degranulation after adhesion is decreased compared to in wild-type mice

abnormal inflammatory response ( J:113463 )

• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit no hemorrhages and reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice

• however, neutrophil migration is normal

hematopoietic system

abnormal neutrophil physiology ( J:113463 )

• neutrophil degranulation after adhesion is decreased compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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