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Phenotypes Associated with This Genotype
Genotype
MGI:3784837
Allelic
Composition
F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Mslb mutation (2 available); any F2rl1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following sensitization with ovalbumin and exposure to ovalbumin, IgE levels are 4-fold lower than in similarly trated wild-type mice
• following sensitization with ovalbumin and exposure to ovalbumin, mice exhibit a 64% reduction in cellular inflammatory infiltrate in bronchoalveolar lavage (specifically, 73% less eosinophils, 71% less neutrophils, 49% less macrophages, and 59% less lymphocytes) compared to in similarly treated wild-type mice
• however, cellular composition of the inflammatory infiltrate is normal

hematopoietic system
• following sensitization with ovalbumin and exposure to ovalbumin, IgE levels are 4-fold lower than in similarly trated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory