Phenotypes Associated with This Genotype

Genotype
MGI:3784586

• Allelic Composition: Dab1^scm/Dab1^scm
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal retina rod bipolar cell morphology ( J:71970 )

• density of cells is decreased, indicating a decreased number of rod bipolar cells compared to controls

vision/eye

abnormal retina rod bipolar cell morphology ( J:71970 )

• density of cells is decreased, indicating a decreased number of rod bipolar cells compared to controls

abnormal retina inner nuclear layer morphology ( J:71970 )

• density of synaptic terminals is decreased compared to controls

abnormal cone electrophysiology ( J:71970 )

• cone mediated-responses are reduced in amplitude and delayed in mutants; difference compared to wild-type cone function is not as great as differences in rod function

abnormal rod electrophysiology ( J:71970 )

• amplitude of a-wave of ERG in response to bright light flash is smaller than in controls while the b-wave is significantly reduced

• oscillatory potentials (OPs) are reduced in amplitude