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Phenotypes Associated with This Genotype
Genotype
MGI:3784572
Allelic
Composition		 Car2n/Car2n
Car9tm1Spas/Car9+
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (21 available)
Car9tm1Spas mutation (1 available); any Car9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal duodenum morphology ( J:102478 )
• some mutants exhibit intraepithelial lymphocytes in the duodenum
gastric gland atrophy ( J:102478 )
• 13% of mutants have mild glandular atrophy
stomach epithelial hyperplasia ( J:102478 )
• 50% of mutants have mild pit-cell hyperplasia
gastric cyst ( J:102478 )
• 50% of mutants have gastric cysts
abnormal digestive system physiology ( J:102478 )
• bicarbonate secretory response of the duodenum to prostaglandin E2 (PGE2) is completely absent in mutants

endocrine/exocrine glands
gastric gland atrophy ( J:102478 )
• 13% of mutants have mild glandular atrophy

growth/size/body
gastric cyst ( J:102478 )
• 50% of mutants have gastric cysts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory