Phenotypes Associated with This Genotype

Genotype
MGI:3784380

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(GFAP-APOE_i4)#Hol/0
• Genetic Background: B6.Cg-Apoe^tm1Unc Tg(GFAP-APOE_i4)#Hol

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to new environment ( J:71062 )

• mice require more time to habituate to a novel environment compared to wild-type mice

abnormal spatial learning ( J:71062 )

• at 14 to 17 months of age, mice did not perform as well as Apoe^tm1Unc homozygotes and Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/Apoe^tm1Unc mice in a rotating holeboard test

• however, mice perform as well as wild-type mice in a rotating holeboard test

impaired spatial working memory ( J:71062 )

• mice exhibit an impairment in working memory in a radial arm maze test compared to wild-type mice

decreased startle reflex ( J:71062 )

• compared to wild-type mice

abnormal stationary movement ( J:71062 )

• mice exhibit increased numbers of fine movement (not related to ambulation) compared to wild-type mice

abnormal locomotor behavior ( J:71062 )

• mice spend less time than wild-type mice and Apoe^tm1Unc homozygotes in the center of an open field