Phenotypes Associated with This Genotype

Genotype
MGI:3783835

• Allelic Composition: Rag1^tm1Bal/Rag1^tm1Bal; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD8-positive, alpha-beta T cell number ( J:133645 )

• OVA-specific CD8 T cells make up 97% of cells found in lymph nodes and 24% of cells in spleen

abnormal CD4-positive, alpha beta T cell morphology ( J:133645 )

• many of the CD4 T cells express the transgenic TCR alpha chain

decreased CD4-positive, alpha-beta T cell number ( J:133645 )

• CD4 T cells make up less than 1% of total cells found in lymph nodes or spleen

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:133645 )

• OVA-specific CD8 T cells make up 97% of cells found in lymph nodes and 24% of cells in spleen

abnormal CD4-positive, alpha beta T cell morphology ( J:133645 )

• many of the CD4 T cells express the transgenic TCR alpha chain

decreased CD4-positive, alpha-beta T cell number ( J:133645 )

• CD4 T cells make up less than 1% of total cells found in lymph nodes or spleen