Analysis Tools
immune system
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• in response to Con A
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• as determined by FACS and ELISA, CD4+ T cells differentiate into Th17 cell less efficiently than wild-type cells without an increase in Th1 differentiation
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• mice exhibit slightly reduced splenic T cells comapred to in wild-type mice
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• slightly
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• CD-28 mediated IL-2 production is half of that in similarly treated wild-type cells
• however, TCR-mediated IL-2 production is normal
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• the onset of experimentally induced autoimmune encephalomyelitis is delayed compared to in wild-type mice
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hematopoietic system
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• in response to Con A
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• as determined by FACS and ELISA, CD4+ T cells differentiate into Th17 cell less efficiently than wild-type cells without an increase in Th1 differentiation
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• mice exhibit slightly reduced splenic T cells comapred to in wild-type mice
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• slightly
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endocrine/exocrine glands
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• slightly
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cellular
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• in response to Con A
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