Phenotypes Associated with This Genotype

Genotype
MGI:3783712

• Allelic Composition: Socs1^tm1Ayos/Socs1^tm1Ayos; Tg(Lck-cre)1Jtak/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:132905 )

• IL-17 producing CD4+ T cells differentiated in vitro and induced with IL-6 and TGF-beta with the anti-TCR antibody results in stronger induction of IFN-gamma producing cells and a marked reduction of IL-17 producing cells in contrast to similarly treated wild-type cells

• CD4+ T cells preferentially differentiate into Th1 cells and not Th17 unlike wild-type cells

abnormal CD4-positive, alpha-beta T cell physiology ( J:132905 )

• CD4+ T cells are resistant to the suppressive effects of TGF-beta on IGN-gamma production unlike wild-type cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:132905 )

• mice are less susceptible to experimental autoimmune encephalomyelitis (EAE) and produce less IL-17 following EAE compared to wild-type mice

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:132905 )

• IL-17 producing CD4+ T cells differentiated in vitro and induced with IL-6 and TGF-beta with the anti-TCR antibody results in stronger induction of IFN-gamma producing cells and a marked reduction of IL-17 producing cells in contrast to similarly treated wild-type cells

• CD4+ T cells preferentially differentiate into Th1 cells and not Th17 unlike wild-type cells

abnormal CD4-positive, alpha-beta T cell physiology ( J:132905 )

• CD4+ T cells are resistant to the suppressive effects of TGF-beta on IGN-gamma production unlike wild-type cells