About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3783542
Allelic
Composition		 Cops5tm1Rpar/Cops5tm1Rpar
Tg(Lck-cre)548Jxm/0
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cops5tm1Rpar mutation (0 available); any Cops5 mutation (26 available)
Tg(Lck-cre)548Jxm mutation (2 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (236 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:132114 )
• an 80-90% reduction compared to control showing no rescue of the reduced thymic cellularity resulting from Cops5 deficiency

immune system
decreased thymocyte number ( J:132114 )
• an 80-90% reduction compared to control showing no rescue of the reduced thymic cellularity resulting from Cops5 deficiency

endocrine/exocrine glands
decreased thymocyte number ( J:132114 )
• an 80-90% reduction compared to control showing no rescue of the reduced thymic cellularity resulting from Cops5 deficiency

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory