Phenotypes Associated with This Genotype

Genotype
MGI:3783526

• Allelic Composition: Rb1^tm3Tyj/Rb1^tm3Tyj; Tg(Pax6-cre,GFP)2Pgr/0
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:91406 )

• extensive at P4 and P12

abnormal retina morphology ( J:91406 )

• ectopic S-phase and mitotic activity are detected unlike in wild-type mice throughout the entire retina

decreased retina ganglion cell number ( J:91406 )

• at E18.5, in the retinal ganglion cell layer

absent retina bipolar cells ( J:91406 )

abnormal retina inner nuclear layer morphology ( J:91406 )

• some inner cell layer cells are very large and of horizontal cell lineage

thin retina inner nuclear layer ( J:91406 )

abnormal retina inner plexiform layer morphology ( J:91406 )

• disorganized

thin retina inner plexiform layer ( J:91406 )

thin retina outer nuclear layer ( J:91406 )

nervous system

gliosis ( J:91406 )

• in the retina at 3 weeks of age

decreased retina ganglion cell number ( J:91406 )

• at E18.5, in the retinal ganglion cell layer

absent retina bipolar cells ( J:91406 )

cellular

gliosis ( J:91406 )

• in the retina at 3 weeks of age

increased retina apoptosis ( J:91406 )

• extensive at P4 and P12