Analysis Tools
mortality/aging
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• mutant pups are born at appropriate Mendelian ratio
• after birth, about one third of mutant mice die on postnatal day 1
• all remaining mutant mice die by P17
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behavior/neurological
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• mice surviving beyond P1 cannot easily regain posture when placed on their backs
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• mice surviving beyond P1 display uncoordinated limb movements, and move primarily by writhing on their abdomen
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growth/size/body
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• mice surviving beyond P1 are severely runted, likely due to feeding problems secondary to their movement disorder
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nervous system
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• severe defect in postnatal cerebellar growth
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