Phenotypes Associated with This Genotype

Genotype
MGI:3779016

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}/Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}; Tg(Agrp-cre)1Gsb/?
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:133218 )

• mice on a normal chow diet weigh 10% less than littermate controls from weaning until 20 weeks of age

• differences are more pronounced when mice are kept on a high fat diet with mice weighing 15-20% less until the age of 20 weeks

homeostasis/metabolism

decreased circulating adrenaline level ( J:133218 )

• there is a significant decrease in plasma epinephrine levels in mice fed a normal diet but not in mice fed a high-fat diet

decreased circulating noradrenaline level ( J:133218 )

• there is a significant decrease in plasma norepinephrine levels in mice fed a normal diet but not in mice fed a high-fat diet

increased oxygen consumption ( J:133218 )

• 9 week old mice consume 15-20% more oxygen during both day and night phases

• 13 week old mice consume more than 30% oxygen during the light phase and more than 40% oxygen during the night phase

abnormal glucose homeostasis ( J:133218 )

decreased circulating glucose level ( J:133218 )

• a 16 hour fasts leads to significantly lower blood glucose levels in mice fed a high fat diet compared to controls

decreased circulating insulin level ( J:133218 )

• mice on a high fat diet have slightly less circulating insulin levels

improved glucose tolerance ( J:133218 )

• mice on a high fat diet are significantly more glucose tolerant compared to controls

adipose tissue

decreased gonadal fat pad weight ( J:133218 )

• mice of either sex on a normal chow diet displayed a 30% reduction in epigonodal fat-pad weight at 20 weeks of age

• mice on a high fat diet displayed a 40-60 % weight reduction in the epigonodal fat pads at 20 weeks of age

behavior/neurological

polyphagia ( J:133218 )

• mice exhibit a slight postpubertal hyperphagia

increased locomotor activity ( J:133218 )

• at 9 weeks of age, mice exhibit a dramatic increase in basal locomotor activity with a 40% increase during the light phase and 60% during the dark phase compared to control mice

• mice exhibit the highest locomotor activity at the beginning of the dark cycle where they were more than twice as active as their littermate controls

• there are also greater increases in fasting-induced hyperactivity than in control mice