About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3778087
Allelic
Composition		 Lrp8tm1Her/Lrp8tm1Her
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp8tm1Her mutation (1 available); any Lrp8 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Disruption of hippocampal layers in Lrp8tm1Her/Lrp8tm1Her, Pafah1b1tm1Awb/Pafah1b1+, and Lrp8tm1Her/Lrp8tm1Her Pafah1b1tm1Awb/Pafah1b1+ mice

nervous system
abnormal hippocampus pyramidal cell layer ( J:129338 )
• mutants exhibit a modest split of the pyramidal layer in area CA1 and CA3
abnormal cerebral cortex morphology ( J:129338 )
• cortical layer abnormalities, with some laminar dispersion of upper layer neurons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory