Phenotypes for Lrp8 Pafah1b1 MGI:3778082 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lrp8^tm1Her/Lrp8^tm1Her Pafah1b1^tm1Awb/Pafah1b1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp8^tm1Her mutation (1 available); any Lrp8 mutation (41 available)
Pafah1b1^tm1Awb mutation (0 available); any Pafah1b1 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Disruption of hippocampal layers in Lrp8^tm1Her/Lrp8^tm1Her, Pafah1b1^tm1Awb/Pafah1b1⁺, and Lrp8^tm1Her/Lrp8^tm1Her Pafah1b1^tm1Awb/Pafah1b1⁺ mice

nervous system

abnormal hippocampus layer morphology ( J:129338 )

• profound dyslamination of all cellular layers in the hippocampus

• however, no gross abnormalities are seen in the cerebellum

abnormal cerebral cortex morphology ( J:129338 )

• inversion of cortical layers

• cortex shows hypercellularity of layer I

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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