behavior/neurological
• mice show mild defect in spatial learning
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• mice have mild but significant impairment in spatial learning and memory
• in the Morris water maze paradigm, mutants and wild-type mice show improvements in performance for the initial 7 days of training, but for the last 3-5 days, mutant performance plateaus while control mice continue to improve in finding the hidden platform
• in probe trials, mutants diplay fewer crossings of the target quadrant after 10 days of training compared to wild-type mice
• similar results are obtained when platform position is changed and test is repeated
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nervous system
N |
• examination of brains at P18, 20, 22, and 3 months shows no gross abnormalities
• no increase in apoptosis is observed at any ages examined
• normal synaptic transmission and plasticity in the Schaeffer collateral pathway are observed
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• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated
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homeostasis/metabolism
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated
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