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Phenotypes Associated with This Genotype
Genotype
MGI:3777985
Allelic
Composition
Psen1tm2Shn/Psen1tm2.1Shn
Tg(Camk2a-cre)1Shn/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2.1Shn mutation (0 available); any Psen1 mutation (44 available)
Psen1tm2Shn mutation (1 available); any Psen1 mutation (44 available)
Tg(Camk2a-cre)1Shn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show mild defect in spatial learning
• mice have mild but significant impairment in spatial learning and memory
• in the Morris water maze paradigm, mutants and wild-type mice show improvements in performance for the initial 7 days of training, but for the last 3-5 days, mutant performance plateaus while control mice continue to improve in finding the hidden platform
• in probe trials, mutants diplay fewer crossings of the target quadrant after 10 days of training compared to wild-type mice
• similar results are obtained when platform position is changed and test is repeated

nervous system
N
• examination of brains at P18, 20, 22, and 3 months shows no gross abnormalities
• no increase in apoptosis is observed at any ages examined
• normal synaptic transmission and plasticity in the Schaeffer collateral pathway are observed
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated

homeostasis/metabolism
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory