Phenotypes for Tg(Ela1-TAg*)79Mjt MGI:3777580 MGI Mouse

decreased tumor-free survival time ( J:78026 )

• almost all mice develop life-threatening tumors and become moribund between 16 and 31 weeks of age

distended abdomen ( J:78026 )

• many animals show evidence of abdominal distention from tumor formation

increased pancreas tumor incidence ( J:78026 )

• mice develop single or multiple pancreatic tumors; one large or multiple small tumors are found within or replacing the pancreas

• tumors are soft and gray with multiple red cystic or hemorrhagic foci

• animals examined between 16 and 26 weeks display acinar cell adenomas and dysplastic acinar cells

• pancreas consists of acinar cell carcinoma cells instead of normal tissue in some severe cases

• mice examined at 10 and 16 weeks of age show pancreatic acinar cell carcinomas

increased metastatic potential ( J:78026 )

• in some mice, largest tumors metastasize to liver, and in some cases to the mesenteric lymph nodes or serosa of diaphragm

abnormal pancreas morphology ( J:78026 )

• in larger tumors, foci of necrosis almost completely replaced normal pancreas tissue

• pancreatic tissue between tumors is dense, firm and whiter than normal, containing multiple foci of small hemorrhagic cysts

• normal acinar tissue is absent when pancreas of each tumor-bearing animal is examined

• newborn transgenic mice display lack of normal pancreas tissue and show only dysplastic acinar tissue